James P. O'Callaghan, PhD

Research Interests

Molecular basis of glial responses to neural injury

Publications

2018

• Koo BB, Michalovicz LT, Calderazzo S, Kelly KA, Sullivan K, Killiany RJ, O'Callaghan JP (2018). Corticosterone potentiates DFP-induced neuroinflammation and affects high-order diffusion imaging in a rat model of Gulf War Illness. Brain Behav Immun, 67:42-46.

2017

• O'Callaghan JP, Michalovicz LT, Miller JV, Kelly KA (2017). Advancing the role of neuroimmunity and genetic susceptibility in Gulf War Illness. EBioMedicine, 26:11-12.
• Bowyer JF, Tranter KM, Sarkar S, George NI, Hanig JP, Michalovicz LT, Miller DB, O'Callaghan JP (2017). Corticosterone and exogenous glucose alter blood glucose levels, neurotoxicity, and vascular toxicity produced by methamphetamine. J Neurochem, 143(2):198-213. Cover image for this issue: doi.10.1111/jnc.13819
• Locker AR, Michalovicz LT, Kelly KA, Miller JV, Miller DB, O'Callaghan JP (2017). Corticosterone primes the neuroinflammatory response to Gulf War Illness-relevant organophosphates independently of acetylcholinesterase inhibition. J Neurochem, 142(3):444-455. PMCID: PMC5575502
• Miner NB, O'Callaghan JP, Phillips TJ, Janowsky A (2017). The combined effects of 3,4-methylenedioxymethamphetamine (MDMA) and selected substituted methcathinones on measures of neurotoxicity. Neurotoxicol Teratol, 61:74-81. PMCID: PMC5453829
• Miller DB, O'Callaghan JP (2017). New horizons for focused ultrasound (FUS) - therapeutic applications in neurodegenerative diseases. Metabolism, 69S:S3-S7.

2016

• O'Callaghan JP, Michalovicz LT, Kelly KA (2016). Supporting a neuroimmunie basis of Gulf War Illness. EBioMedicine, 13:5-6. PMCID: PMC5264477
• Alam G, Miller DB, O'Callaghan JP, Lu L, Williams RW, Jones BC (2016). MPTP neurotoxicity is highly concordant between the sexes among BXD recombinant inbred mouse strains. Neurotoxicology, 55:40-47. PMCID: PMC5051270
• Bowyer JF, Sarkar S, Tranter KM, Hanig JP, Miller DB, O'Callaghan JP (2016). Vascular-directed responses of microglia produced by methamphetamine exposure: indirect evidence that microglia are involved in vascular repair? J Neuroinflammation, 13(1):64. PMCID: PMC4789274

2015

•  Miller, D.B. and O’Callaghan, J.P.: Biomarkers of Parkinson’s disease (PD): where we are and where we are going.  Metabolism 64:  S40-6, 2015.

2014

• O’Callaghan, J.P., Daughtrey, W.C., Clark, C.R., Schreiner, C.A. and White, R.: Health Assessment of Gasoline and Fuel Oxygenate Vapors:  Neurotoxicity Evaluation. Regulatory Toxicol. Pharmacol. 70: S35-S42, 2014.
• Jones, B.C., O’Callaghan, J.P., Lu, L., Williams, R.W., Alama, G., Miller, D.B. Genetic             Correlational Analysis Reveals no Association between MPP+ and the Severity of Striatal Dopaminergic Damage Following MPTP Treatment in BXD mouse strains.  Neurotoxicol. Teratol. 45: 91-92, 2014.
• Panos, J.J., O’Callaghan, J.P., Miller, D.B. and Ferguson, S.A.: Effects of developmental methylphenidate (MPH) treatment on monoamine neurochemistry of male and female rats.  Neurotoxicology 45: 70-74, 2014.
• Elliott, A.S., Huber, J.D., O’Callaghan, J.P., Rosen, C.L. and Miller, D.B.:  A review of sleep deprivation studies evaluating the brain transcriptome. SpringerPlus 3: 728, 2014.

In press/In house review/Submitted

• Matsumoto, R.R., Seminerio, M.J., Turner, R.C., Robson, M.J., Miller, D.B. and O’Callaghan, J.P.: Methamphetamine-induced toxicity: an updated review on issues relate to hyperthermia. Pharmacol. Ther. (in press).
• Gray, T.M., Steup, D., Roberts, L.G., O’Callaghan, J.P., Hoffman, G., Schreiner, C. and Clark, C.R.: Health Assessment of Gasoline and Fuel Oxygenate Vapors: Reproductive Toxicity Assessment. Regulatory Toxicol Pharmacol. (in press).
• O’Callaghan, J.P., Kelly, K.A., Locker, A.R., Miller, D.B. and Lasley, S.M.: Corticosterone Primes the  Neuroinflammatory Response to DFP in Mice:  Potential Animal Model of  Gulf War Illness J. Neurochem.  2015 Mar 5. doi: 10.1111/jnc.13088.
• Roberts R., Aschner M., Calligaro D., Guilarte T.R., Hanig J.P., T Herr D., Hudzik, T.J., Jeromin, A., Kallman M.J., Liachenko S., Lynch J.J. III, Miller D.B., Moser V.C., O’Callaghan J., Slikker W. Jr., Paule, M.G. Translational Biomarkers of Neurotoxicity: the Way Forward?  Tox Sci. (in house review)
• White, R.F., Steele, L., O’Callaghan, J.P., Sullivan, K., Barlow, C., Binns, J.H., Bloom, F.E., Bunker, J.A., Crawford, F., Golomb, B.A., Graves, J.C., Hardie, A., Klimas, N,  Knox, M, Meggs, W., Melling, J., Ondra, S.L., Philbert, M.A., Grashow, R.: Gulf War illness and other health problems in veterans of the 1990-1991 Gulf War:  Effects of exposures to neurotoxicants.  Cortex (submitted).